UPenn's DM-Renal-Electrolyte Hypertens

UPenn's DM-Renal-Electrolyte Hypertens HELP US FIND A WAY
TO TAKE DOWN UNCONTROLLED BLOOD PRESSURE
INTRODUCING THE SPYRAL HTN GLOBAL CLINIC

Do you have or someone you know have Uncontrolled High Blood Pressure

The Hospital of the University of Pennsylvania
is participating in two new global clinical trials investigating the effect of renal denervation with the Investigational Simplicity Spyral™ catheter and Simplicity G3™ radiofrequency (RF) generator. Renal denervation is a minimally invasive, catheter-based procedure that may poten

tially calm the activity of nerves within the arteries leading to the kidneys. These nerves are part of the sympathetic nervous system, which helps the body control blood pressure. In people with hypertension, the renal nerves are hyperactive, raising blood pressure and contributing to heart, kidney and blood vessel damage. The two separate trials being conducted at the Hospital of the University of Pennsylvania are investigating the effect of renal denervation on high blood pressure in patients who are and who are not currently taking medications to lower their blood pressure.

“Uncontrolled high blood pressure is one of the greatest threats to patients living in Philadelphia,” said Debbie Cohen, M.D. in a recent Press Release and “We are proud to have been selected to take part in these groundbreaking trials, and look forward to helping identify which patients might be the most appropriate for this investigational treatment.”

Caution: The Symplicity™ Spyral™ catheter and Symplicity G3TM Generator are investigational devices and are limited by Federal Law to investigational use.

02/24/2016
02/24/2016

Do you have HIGH BLOOD PRESSURE?

The University of Pennsylvania Health System, Renal Medicine
Is conducting a research trial on the effects of a new investigational procedure as a possible treatment for high blood pressure

You may be eligible to participate if you:
• Are between 20 and 80 years of age
• Have high blood pressure (Systolic blood pressure or top number between 150-180)
• NOT taking medication for your blood pressure

Participation Includes:
• Several clinic visits over a three year period, including blood draws and urine samples
• 24-hour ambulatory blood pressure monitoring
• A study procedure that includes an angiogram (x-rays of the blood vessels to your kidneys)
• Ultrasound and/or MRI of your kidneys
• Overnight hospital stay with the study procedure
• Quality of Life assessments

Caution: The Symplicity™ Spyral™ catheter and Symplicity G3TM Generator are investigational devices and are limited by Federal Law to investigational use. This procedure is not for everyone and does carry some risk.

For more information, please contact:

Robin Neubauer, RN
Department of Nephrology
215-615-0773

02/24/2016

Do you have HIGH BLOOD PRESSURE?

The University of Pennsylvania Health System, Renal Medicine
Is conducting a research trial on the effects of a new investigational procedure as a possible treatment for high blood pressure

You may be eligible to participate if you:
• Are between 20 and 80 years of age
• Have high blood pressure (Systolic blood pressure or top number between 140-175)
• Are taking three or more medications and a diuretic for your blood pressure

Participation Includes:
• Several clinic visits over a three year period, including blood draws and urine samples
• 24-hour ambulatory blood pressure monitoring
• A study procedure that includes an angiogram (x-rays of the blood vessels to your kidneys)
• Ultrasound and/or MRI of your kidneys
• Overnight hospital stay with the study procedure
• Quality of Life assessments

Caution: The Symplicity™ Spyral™ catheter and Symplicity G3TM Generator are investigational devices and are limited by Federal Law to investigational use. This procedure is not for everyone and does carry some risk.

For more information, please contact:

Robin Neubauer, RN
Department of Nephrology
215-615-0773

12/21/2015

Renal sympathetic denervation, or renal denervation , is a minimally invasive, endovascular catheter based procedure using radiofrequency ablation or ultrasound ablation aimed at treating resistant hypertension . Nerves in the wall of the renal artery are ablated by applying radiofrequency pulses or ultrasound to the renal arteries. This causes reduction of sympathetic afferent and efferent activity to the kidney and blood pressure can be decreased. Early data from international clinical trials without sham controls was promising - demonstrating large blood pressure reductions in patients with treatment-resistant hypertension. However, in 2014 a prospective, single-blind, randomized, sham-controlled clinical trial failed to confirm a beneficial effect on blood pressure. A 2014 consensus statement from The Joint UK Societies did not recommend the use of renal denervation for treatment of resistant hypertension on current evidence.

Address

Perelman Center For Advnce Medicine 3400 Civic Center Boulevard, 1st FL South Pavilion
Philadelphia, PA
19104

Telephone

215-615-0773

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